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Effect of charcoal-broiled beef on phenacetin metabolism in man
Science (New York, N.Y.)
|December 3, 1976
Abstract:
When charcoal-broiled beef was fed to human volunteers, who were then given phenacetin orally, the concentration of phenacetin in the plasma was lowered, but its half-life in the plasma was not changed. The data suggest that feeding charcoal-broiled beef enhances the metabolism of orally administered phenacetin in the intestine or during its first pass through the liver, or both.