Differential expression of a conserved new mRNA in lymphoid cells
H Illges1, U Krawinkel, A Radbruch
1Universität Konstanz, Fakultät Biologie, Germany.
Abstract:
We describe a polyadenylated RNA (Drld = Differentially regulated in lymphoid organs and differentiation) from murine lymphocytes. Two homologous molecular forms of this RNA of approximately 500 and 900 bases are detected in various tissues and lymphoid cell lines. Southern blotting showed that up to ten highly homologous loci exist which in part are polymorphic between the different mouse strains analyzed. Cross-hybridizing loci can be detected in distantly related species such as horse, fish and Drosophila melanogaster. Sequence analysis revealed homologies to the untranslated region of the GPI-linked murine B7(2) antigen, the B2 repetitive elements and 3 untranslated genes. Drld apparently defines a new family of genetic elements.
Related Concept Videos
RNA Splicing
Alternative RNA Splicing
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Leaky Scanning
lncRNA - Long Non-coding RNAs
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Ribosome Profiling
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...


