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Related Experiment Videos

Selenium status in fibromyalgia

P Reinhard1, F Schweinsberg, D Wernet

  • 1Chemisches Labor, Abteilung Allgemeine Hygiene und Umwelthygiene, Hygiene-Institut, Universität Tübingen, Germany.

Toxicology Letters
|November 20, 1998
PubMed
Summary

This study found lower serum selenium (Se) levels in fibromyalgia patients compared to healthy individuals. These findings suggest a potential link between selenium deficiency and fibromyalgia symptoms.

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Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Nutritional Science

Background:

  • Fibromyalgia (FM) is a chronic pain condition with an unknown cause.
  • Selenium (Se) is an essential trace element with antioxidant properties.

Purpose of the Study:

  • To investigate serum selenium concentrations in patients diagnosed with fibromyalgia.
  • To compare selenium levels between fibromyalgia patients and a healthy control group.

Main Methods:

  • Serum selenium levels were quantified using high-performance liquid chromatography (HPLC).
  • The method involved derivatization with diaminonaphthalene (DAN) for fluorescence detection of selenite.
  • Patients and controls were age- and sex-matched for comparison.

Main Results:

  • Fibromyalgia patients exhibited a statistically significant lower median serum selenium level (71 microg/l) compared to the control group (77 microg/l).
  • Serum Se ranges in patients were 39-154 microg/l, and in controls were 50-118 microg/l.
  • The difference was statistically significant (P < 0.05).

Conclusions:

  • A statistically significant difference in serum selenium levels was observed between fibromyalgia patients and healthy controls.
  • Lower serum selenium may be associated with fibromyalgia.
  • Further research is warranted to explore the role of selenium in fibromyalgia etiology and management.

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