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Ischaemia-reperfusion injury. Implications for the hand surgeon
1Division of Plastic Surgery, King Saud University, Riyadh, Saudi Arabia.
Journal of Hand Surgery (Edinburgh, Scotland)
|November 20, 1998
Abstract:
Prolonged ischaemia sometimes occurs in replantation and free flap surgery. The re-establishment of circulatory flow to the ischaemic tissue leads to a cascade of events which augments tissue necrosis. This paper reviews the pathophysiology of this ischaemia-reperfusion injury and discusses different methods to modulate this injury.