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DNA repair of adriamycin induced damage in mouse and human cells differing in catalase activity
1Department of Vitamin Drugs, Drug Institute, Warsaw, Poland.
Acta Biochimica Polonica
|November 20, 1998
Abstract:
Catalase is known to counteract cytotoxic effect of adriamycin, used as an anti-neoplastic drug. In cells with low catalase activity no repair of adriamycin induced lesions was observed up to 48 h post treatment. In cells with high catalase activity after 48 h the repair was either complete or partial depending on the human or mouse cell type used.