Related Experiment Videos
Adverse effects of vigabatrin in Angelman syndrome
C Kuenzle1, M Steinlin, G Wohlrab
1Department of Pediatric Neurology, University Children's Hospital, Zurich, Switzerland.
Epilepsia
|November 20, 1998
Abstract:
New antiepileptic drugs designed for enhancing GABAergic inhibition, such as vigabatrin (VGB) may be effective in Angelman syndrome (AS), because associated convulsions could be related to a reduced GABA-receptor density or receptor abnormality. From our preliminary experiences in four children with AS treated with VGB, we conclude that it may induce and increase seizures in patients with AS.