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Repetitive post-training exposure to enflurane modifies spatial memory in mice

H Komatsu1, J Nogaya, N Kuratani

  • 1Department of Anesthesiology and Emergency Medicine, Kagawa Medical University, Miki, Japan. komatsu@kms.ac.jp

Anesthesiology
|November 20, 1998
PubMed
Summary

Repetitive exposure to enflurane, an anesthetic, significantly improved spatial memory in mice. This suggests enflurane may enhance memory consolidation, potentially by influencing hippocampal function.

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Area of Science:

  • Neuroscience
  • Anesthesiology
  • Cognitive Science

Background:

  • Previous studies indicated anesthetics like enflurane and isoflurane enhance memory storage in active avoidance tasks.
  • Spatial memory tasks are known to rely on hippocampal functions, unlike active avoidance tasks.

Purpose of the Study:

  • To investigate the impact of repetitive post-training enflurane exposure on spatial memory in mice.
  • To determine if enflurane affects memory consolidation in a hippocampus-dependent task.

Main Methods:

  • Eighty mice were trained on an eight-arm radial maze over four consecutive days.
  • Mice received daily post-training exposure to 0.5%, 1%, or 2% enflurane or air (control) for 1 hour.
  • Performance was assessed by recording errors in choices on the maze.

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Main Results:

  • Mice exposed to 1% and 2% enflurane showed significantly enhanced spatial memory performance compared to controls.
  • Performance ratios (Day 4 errors/Day 1 errors) were 0.32 for 1% enflurane (P < 0.01) and 0.46 for 2% enflurane (P < 0.05).
  • The 0.5% enflurane group showed no significant difference from the control group.

Conclusions:

  • Repetitive post-training exposure to 1% and 2% enflurane significantly improved spatial memory consolidation.
  • Enflurane's memory-enhancing effects may be mediated by its influence on hippocampal activity.