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Updated: Jul 4, 2026

Isolation of Brain-infiltrating Leukocytes
06:44

Isolation of Brain-infiltrating Leukocytes

Published on: June 13, 2011

Isolated leptomeningeal Castleman's disease with viral particles in the follicular dendritic cells

P Gulati1, N C Sun, B K Herman

  • 1Department of Pathology, University of California at Los Angeles-Harbor Medical Center, Torrance, USA.

Archives of Pathology & Laboratory Medicine
|November 20, 1998
PubMed

Insights

This study reports a rare case of Castleman

Area of Science:

  • Neurology
  • Oncology
  • Virology

Background:

  • Castleman's disease is a rare lymphoproliferative disorder.
  • Central nervous system (CNS) involvement is exceptionally uncommon, with only five prior reported cases.
  • This report details the sixth known instance of CNS-exclusive Castleman's disease.

Observation:

  • A 47-year-old woman presented with a 3-month history of headaches.
  • Neuroimaging revealed a large mass in the superior frontal lobe.
  • Excisional biopsy confirmed Castleman's disease morphology.

Findings:

  • Histopathology showed characteristic lymphoid nodules with germinal centers and B lymphocyte proliferation.
  • Ultrastructural analysis identified 100-nm virallike particles resembling a D-type retrovirus within follicular dendritic cells and intercellular spaces.
  • These viral particles represent a novel finding in CNS Castleman's disease.

Implications:

  • This case expands the understanding of Castleman's disease presentation and potential viral associations.
  • The findings may prompt further research into retroviral roles in lymphoproliferative disorders.
  • Successful management with surgery and radiotherapy highlights treatment possibilities for this rare condition.

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