Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitoxantrone in malignant pericardial effusion

J Norum1, P Lunde, U Aasebø

  • 1Department of Oncology, University Hospital of Tromsø, Norway. jnnor@online.no

Journal of Chemotherapy (Florence, Italy)
|November 20, 1998
PubMed
Summary

Intrapericardial mitoxantrone instillation offers a safe and simple treatment for malignant pericardial effusion (MPE). This method showed promising results in patients with advanced cancers, improving survival and quality of life.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disease course and symptoms in smoking versus non-smoking patients with Celiac disease.

Acta gastro-enterologica Belgica·2026
Same author

Interaction of three-dimensional acoustic beam with fluid-loaded solid plate: Axial near- to far-field transmission at normal beam incidence.

Ultrasonics·2022
Same author

Treatment of acute myocardial infarction in the sub-arctic region of Norway. Do we offer an equal quality of care?

International journal of circumpolar health·2017
Same author

Utilisation of novel anti-platelet agents: evidence, guidelines and proven patients' value.

Thrombosis and haemostasis·2014
Same author

Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial.

Diabetes, obesity & metabolism·2013
Same author

Concurrent palliative chemoradiation leads to survival and quality of life benefits in poor prognosis stage III non-small-cell lung cancer: a randomised trial by the Norwegian Lung Cancer Study Group.

British journal of cancer·2013

Area of Science:

  • Oncology
  • Cardiology
  • Medical Procedures

Background:

  • Malignant pericardial effusion (MPE) is often a late-stage complication of various cancers.
  • Existing treatments for MPE include chemotherapy, radiotherapy, and surgical or catheter-based drainage procedures.
  • Mitoxantrone has demonstrated efficacy in treating malignant pleural effusions.

Purpose of the Study:

  • To evaluate the safety and efficacy of ultrasound-guided pericardiocentesis followed by intrapericardial mitoxantrone instillation for managing life-threatening MPE.
  • To assess treatment outcomes in patients with MPE secondary to breast and ovarian cancers.

Main Methods:

  • A cohort of 5 patients with life-threatening MPE (4 breast cancer, 1 ovarian cancer) between 1992-1997 underwent the procedure.
  • Treatment involved ultrasound-guided pericardiocentesis and subsequent instillation of 10 mg mitoxantrone into the pericardial space.

Related Experiment Videos

  • Patients were evaluated at a median follow-up of 59 days.

    • Main Results:

    • Two patients achieved complete response (CR), one had a partial response (PR), and two showed progressive disease (PD).
    • Two patients survived for 213 and 294 days post-treatment, indicating potential survival benefit.
    • The procedure was deemed safe and simple for managing MPE.

    Conclusions:

    • Intrapericardial mitoxantrone instillation is a safe and effective therapeutic option for malignant pericardial effusion in select cancer patients.
    • This minimally invasive approach can be considered for MPE management, particularly in malignancies responsive to mitoxantrone.
    • The study suggests potential for improved outcomes and survival in patients with advanced cancer and MPE.