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Related Experiment Videos

Minocycline-induced cutaneous pigmentation

N R Wasel1, E H Schloss, A N Lin

  • 1Division of Dermatology and Cutaneous Sciences, University of Alberta, Edmonton, Alberta, Canada.

Journal of Cutaneous Medicine and Surgery
|November 21, 1998
PubMed
Summary
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Minocycline, an antibiotic, can cause bluish-grey skin pigmentation, particularly on the legs and forearms. This side effect, often seen in acne patients, can also occur in those treated for rheumatoid arthritis.

Area of Science:

  • Dermatology
  • Rheumatology
  • Pharmacology

Background:

  • Minocycline-induced cutaneous pigmentation is a recognized adverse effect.
  • It is typically observed in patients on long-term minocycline for acne vulgaris.

Observation:

  • A 69-year-old woman developed bluish-grey pigmentation on her legs and forearms.
  • The pigmentation appeared approximately 3 months after starting minocycline for rheumatoid arthritis.

Findings:

  • Minocycline therapy, even for inflammatory conditions like rheumatoid arthritis, can lead to cutaneous pigmentation.
  • The pigmentation primarily affected the legs and forearms in this patient.

Implications:

  • Clinicians should be aware of minocycline-induced pigmentation in patients with rheumatoid arthritis.

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  • Differential diagnosis is crucial for identifying this pigmentation, which may be more common than previously thought.