Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diblock copolymer nanoparticles for drug delivery

G S Kwon1

  • 1School of Pharmacy, University of Wisconsin at Madison 53706-1508, USA.

Critical Reviews in Therapeutic Drug Carrier Systems
|November 21, 1998
PubMed
Summary

Diblock copolymer nanoparticles offer a promising solution for drug delivery, mimicking natural structures to solubilize, protect, and release medications effectively. These synthetic carriers show potential for sustained release and site-specific delivery, enhancing therapeutic effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibition of DNA Topoisomerase I by Dihydrotanshinone I, Components of a Medicinal Herb Salvia miltiorrhiza Bunge.

Bioscience, biotechnology, and biochemistry·2016
Same author

Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo.

Cancer gene therapy·2014
Same author

Polymeric micelles for drug delivery.

Current pharmaceutical design·2006
Same author

PEG-phospholipid micelles for the delivery of amphotericin B.

Journal of controlled release : official journal of the Controlled Release Society·2005
Same author

Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2005
Same author

Micelles self-assembled from poly(ethylene oxide)-block-poly(N-hexyl stearate L-aspartamide) by a solvent evaporation method: effect on the solubilization and haemolytic activity of amphotericin B.

Journal of controlled release : official journal of the Controlled Release Society·2001

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Diblock copolymers self-assemble into nanoparticles like micelles and nanospheres.
  • These nanoparticles mimic the structure of lipoproteins and viruses.
  • Current research explores their potential as carriers for hydrophobic drugs and genes.

Purpose of the Study:

  • To investigate the functional capabilities of diblock copolymer nanoparticles as drug carriers.
  • To evaluate their ability to solubilize, protect, and control the release of therapeutic agents.
  • To explore their potential for site-specific drug delivery and enhanced therapeutic outcomes.

Main Methods:

  • Self-assembly of diblock copolymers into nanoparticle structures (micelles, nanospheres).

Related Experiment Videos

  • Characterization of nanoparticle properties for drug encapsulation and release kinetics.
  • In vivo studies to assess pharmacokinetic profiles and therapeutic efficacy.

    • Main Results:

    • Diblock copolymer nanoparticles demonstrate the ability to solubilize hydrophobic drugs.
    • These nanoparticles provide protection for encapsulated agents and enable sustained release.
    • Studies indicate prolonged residence times in circulation and enhanced drug effects in animal models.

    Conclusions:

    • Diblock copolymer nanoparticles are versatile synthetic carriers with functional attributes for drug delivery.
    • Their ability to mimic natural supramolecular structures contributes to their efficacy.
    • These nanoparticles hold significant potential for advancing site-specific and sustained drug delivery strategies.