Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Three rules for bone adaptation to mechanical stimuli

C H Turner1

  • 1Biomechanics and Biomaterials Research Center, IUPUI, Indianapolis, IN, USA.

Bone
|November 21, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In situ thin film growth stresses during chemical ordering.

Physical review letters·2010
Same author

Skeletal phenotype of mice with a null mutation in Cav 1.3 L-type calcium channel.

Journal of musculoskeletal & neuronal interactions·2010
Same author

Heritability of lumbar trabecular bone mechanical properties in baboons.

Bone·2009
Same author

Rapamycin impairs trabecular bone acquisition from high-dose but not low-dose intermittent parathyroid hormone treatment.

Journal of cellular physiology·2009
Same author

Skeletal health: primate model of postmenopausal osteoporosis.

American journal of primatology·2009
Same author

The surgical senior lecturer.

Annals of the Royal College of Surgeons of England·2009
Same journal

Baseline β-CTX and BMI predict suitability for deferred zoledronic acid redosing beyond 12 months in postmenopausal Indian women with osteoporosis.

Bone·2026
Same journal

Bone density-based maturation of the midpalatal suture in children aged 8-15 years.

Bone·2026
Same journal

Disrupted phosphate metabolism and SIBLING/ASARM peptide accumulation underlie impaired bone mineralization in klotho-deficient (kl/kl) mice.

Bone·2026
Same journal

Linking genetic variants to bone microstructure: Histological signatures of osteogenesis imperfecta subtypes.

Bone·2026
Same journal

The impact of alcohol consumption on bone mineral density: Insights from cross-sectional and Mendelian randomization studies.

Bone·2026
Same journal

Systemic and local predictors of medication-related osteonecrosis of the jaw in patients receiving antiresorptive therapy: The Shizuoka Kokuho Database study.

Bone·2026
See all related articles

Bone adaptation optimizes skeletal structure for efficient locomotion by responding to dynamic loading. Mathematical models describe how bones adjust shape and mass to mechanical demands.

Area of Science:

  • Biomechanics
  • Skeletal Biology
  • Computational Modeling

Background:

  • Bones serve as rigid levers for locomotion, requiring adaptation for efficiency and reduced mass.
  • Skeletal growth and development involve continuous adjustment of bone mass and architecture to mechanical stimuli.

Purpose of the Study:

  • To elucidate the fundamental rules governing bone adaptation.
  • To derive mathematical models for bone adaptation based on established principles.

Main Methods:

  • Analysis of established principles of bone adaptation.
  • Derivation of parametric mathematical models based on three core rules.

Main Results:

  • Identified three key rules for bone adaptation: dynamic loading drive, short-duration response initiation, and accommodation to routine loading.

Related Experiment Videos

  • Developed mathematical equations representing simple parametric models of bone adaptation.

    • Conclusions:

    • Bone adaptation is primarily governed by dynamic mechanical loading.
    • Mathematical models can effectively simulate bone adaptation processes based on these fundamental rules.