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Diabetic vascular disease and hypertension
M Hamaty1, M Lamberti, J R Sowers
1Division of Endocrinology, Metabolism and Hypertension, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Current Opinion in Cardiology
|November 21, 1998
Summary
Essential hypertension often accompanies metabolic issues like insulin resistance and dyslipidemia. Visceral obesity is a key factor, increasing cardiovascular disease risk, especially in African-American women.
Area of Science:
- Cardiology
- Metabolic Syndrome
- Hypertension Research
Background:
- Essential hypertension is increasingly linked to various metabolic abnormalities.
- These include insulin resistance, dyslipidemia, coagulation disorders, and endothelial dysfunction.
Purpose of the Study:
- To explore the relationship between essential hypertension and metabolic abnormalities.
- To identify visceral obesity as a central risk factor for hypertension-related metabolic dysfunction and cardiovascular disease (CVD).
Main Methods:
- Review of existing evidence linking hypertension with metabolic syndrome components.
- Analysis of the role of visceral obesity and oxidative stress in cardiovascular risk.
Main Results:
- Visceral obesity is identified as a common and predictive factor for metabolic abnormalities associated with hypertension.
- Increased cardiovascular disease risk is noted, particularly in high-risk groups like African-American women.
Conclusions:
- Metabolic abnormalities are integral to essential hypertension, with visceral obesity as a primary driver.
- Therapeutic strategies targeting oxidative stress, such as ACE inhibitors, are crucial for managing hypertension and associated CVD risk.