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Anorectal disease in HIV-infected patients
1Division of Colon and Rectal Surgery, Cook County Hospital and University of Illinois, Chicago 60612, USA.
Diseases of the Colon and Rectum
|November 21, 1998
Summary
Anorectal diseases are common in individuals with human immunodeficiency virus (HIV). This study found anal condylomata and painful ulcers are the most prevalent conditions, with a high incidence of anorectal neoplasia in this population.
Area of Science:
- Colorectal Surgery
- Infectious Diseases
- Gastroenterology
Background:
- Anorectal diseases frequently affect individuals with human immunodeficiency virus (HIV).
- Understanding the specific causes and presentations is crucial for effective management.
- HIV infection can alter the immune response, potentially influencing anorectal pathology.
Purpose of the Study:
- To prospectively assess the causes and clinical presentation of anorectal disease in HIV-infected individuals.
- To identify the spectrum of anorectal pathologies in this specific patient group.
- To correlate clinical findings with microbiological and histological data.
Main Methods:
- Prospective data collection from 180 HIV-seropositive patients with anorectal complaints.
- Examination under anesthesia with random cultures and biopsies.
- Specific sampling of suspicious lesions for diagnosis.
Main Results:
- The most common symptoms were anorectal pain (57%), lumps/warts (28%), and bleeding (12%).
- Anal condyloma was the most prevalent pathology (43%), with 10% associated with anal intraepithelial neoplasia.
- Wide-based anal ulcers (32%) were common, often idiopathic, and a high incidence of anorectal neoplasia was noted.
Conclusions:
- HIV infection is linked to a diverse range of anorectal diseases.
- Anal condylomata and painful, often idiopathic, ulcers are the most frequent findings.
- A significant incidence of anorectal neoplasia warrants further investigation in HIV-positive individuals.