Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The p53 tumour suppressor gene

R J Steele1, A M Thompson, P A Hall

  • 1Dundee Cancer Research Institute, Dundee Teaching Hospitals Trust and University of Dundee, UK.

The British Journal of Surgery
|November 21, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enabling DCIS subtyping: leveraging foundation models for robust grading and molecular biomarker scoring.

NPJ breast cancer·2026
Same author

Bridging the age gap in breast cancer: cluster randomized trial of two decision support interventions for older women with operable breast cancer on quality of life, survival, decision quality, and treatment choices.

The British journal of surgery·2021
Same author

Identifying triggers for hidradenitis suppurativa flare: a patient survey.

The British journal of dermatology·2021
Same author

Using observations and source specific model tracers to characterize pollutant transport during FRAPPÉ and DISCOVER-AQ.

Journal of geophysical research. Atmospheres : JGR·2020
Same author

Erythropoietin modulates striatal antioxidant signalling to reduce neurodegeneration in a toxicant model of Parkinson's disease.

Molecular and cellular neurosciences·2020
Same author

Characterizing physical symptoms of flare in hidradenitis suppurativa: a patient survey.

The British journal of dermatology·2020

The p53 tumor suppressor gene is crucial for preventing cancer by initiating cell cycle arrest or apoptosis in response to DNA damage. While its role in cancer is well-established, its clinical applications remain under development.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Abnormalities in the p53 tumor suppressor gene are implicated in a significant percentage of human cancers.
  • This review synthesizes current knowledge regarding the function and clinical relevance of the p53 gene.

Purpose of the Study:

  • To review the function of the p53 tumor suppressor gene.
  • To explore the potential clinical significance of p53 in human cancers.

Main Methods:

  • Literature search including previous reviews, cited references, and Medline database up to January 1998.
  • Scanning of recent publications in relevant scientific journals.

Main Results:

  • The p53 protein acts as a stress response gene, inducing cell cycle arrest or apoptosis to maintain genetic stability.

Related Experiment Videos

  • The p53 pathway involves complex steps and the induction of other gene expressions.

    • Conclusions:

    • p53 is the most frequently mutated gene in human cancer, making it a key area of interest for prognostic, diagnostic, and therapeutic strategies.
    • Despite extensive research, the practical application of p53 in cancer management is yet to be fully realized.