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Association between breast and colorectal cancers

B A Stoll1

  • 1Department of Oncology, St Thomas' Hospital, London, UK.

The British Journal of Surgery
|November 21, 1998
PubMed
Summary

Western lifestyle increases cancer risk in immigrants. High energy intake, obesity, and poor exercise are linked to breast and colorectal cancers, potentially via insulin resistance and insulin-like growth factors (IGFs).

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Area of Science:

  • Oncology
  • Endocrinology
  • Nutritional Science

Background:

  • Immigrants adopting Western lifestyles show increased breast and colorectal cancer risks.
  • Epidemiological studies link these cancers in Western populations, with obesity and inactivity as common risk factors.

Purpose of the Study:

  • To examine risk markers for breast and colorectal cancers.
  • To identify causative nutritional factors and metabolic-endocrine dysfunction.
  • To explore the role of insulin and insulin-like growth factors (IGFs) in carcinogenesis.

Main Methods:

  • Analysis of risk markers for breast and colorectal cancers.
  • Review of epidemiological and laboratory studies.
  • Focus on insulin, insulin-like growth factors (IGFs), and steroid hormones.

Main Results:

  • Hyperinsulinaemia is associated with breast and colorectal cancer.
  • Genetic susceptibility to insulin resistance can lead to hyperinsulinaemia.
  • Increased IGF activity stimulates human breast and colorectal cancer cell growth.

Conclusions:

  • Insulin resistance and associated factors may promote breast and colorectal cancers, or share common risk factors.
  • Dietary n-3 polyunsaturated fatty acids may reduce insulin resistance risk.
  • Modifying hyperinsulinaemia could potentially alter breast and colorectal cancer risk.

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