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Microprocessor controlled movement of liquid gastric content using sequential neural electrical stimulation

M P Mintchev1, C P Sanmiguel, S J Otto

  • 1Department of Electrical and Computer Engineering, University of Calgary, Alberta, Canada.

Gut
|November 21, 1998
PubMed
Summary
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Microprocessor controlled electrical stimulation successfully created artificial peristalsis, significantly accelerating gastric emptying of liquid content in dogs. This method shows promise for treating gastric motility disorders.

Area of Science:

  • Gastroenterology
  • Biomedical Engineering
  • Medical Devices

Background:

  • Gastric electrical stimulation has historically yielded limited success.
  • Previous attempts lacked effective methods for controlling gastric content movement.

Purpose of the Study:

  • To investigate the efficacy of microprocessor-controlled sequential electrical stimulation for inducing gastric content movement.
  • To determine if artificial peristalsis can be achieved and improve gastric emptying.

Main Methods:

  • Eight anesthetized dogs received implanted electrodes for circumferential gastric stimulation.
  • Artificial contractions were generated using phase-locked electrical stimulation (50 Hz, 14 V).
  • Gastric emptying and contractions were monitored, with force transducers used in some subjects.

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Main Results:

  • Stimulation successfully produced and propagated artificial circumferential gastric contractions.
  • Average stimulated gastric emptying time (t1/2 = 6.7 min) was significantly faster than spontaneous emptying (t1/2 = 25.3 min).
  • Electrical stimulation in a gastroparetic patient induced contractions during surgery.

Conclusions:

  • Microprocessor-controlled electrical stimulation effectively creates artificial peristalsis.
  • This technique notably accelerates the movement of liquid gastric content.
  • The findings suggest a potential new therapeutic approach for gastroparesis and related motility disorders.