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Lymphocytic colitis: clinical presentation and long term course

B Mullhaupt1, U Güller, M Anabitarte

  • 1Gastroenterology, Department of Internal Medicine, University Hospital, Rämistrasse 100, CH-8091 Zürich, Switzerland.

Gut
|November 21, 1998
PubMed
Summary

Lymphocytic colitis typically resolves within 38 months, with most patients experiencing symptom and histological remission. This chronic watery diarrhoea condition shows a benign long-term course.

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Area of Science:

  • Gastroenterology
  • Colorectal Diseases
  • Inflammatory Bowel Disease

Background:

  • Lymphocytic colitis presents as chronic watery diarrhea with normal endoscopic findings.
  • Microscopic examination reveals significant lymphocyte infiltration in the colonic mucosa.

Purpose of the Study:

  • To evaluate the long-term clinical and histological progression of lymphocytic colitis.
  • To assess disease evolution in a cohort of well-characterized patients.

Main Methods:

  • Retrospective review of clinical, endoscopic, and histopathological records from 1986-1995.
  • Follow-up examinations, including repeat endoscopy and biopsies, were performed on 27 patients.

Main Results:

  • After a mean follow-up of 37.8 months, 93% of patients achieved remission of diarrhea.

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  • Histological normalization occurred in 82% of patients.
  • No progression from lymphocytic colitis to collagenous colitis was observed.

    • Conclusions:

    • Lymphocytic colitis demonstrates a benign clinical course with high rates of spontaneous resolution.
    • Over 80% of patients experience symptom and histological normalization within approximately 38 months.
    • The favorable prognosis suggests careful consideration of treatment risks versus benefits.