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Related Concept Videos

Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

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Related Experiment Video

Updated: Jul 20, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Fatigue in primary biliary cirrhosis

K Cauch-Dudek1, S Abbey, D E Stewart

  • 1Department of Medicine, Toronto Hospital, University of Toronto, Ontario, Canada.

Gut
|November 21, 1998
PubMed
Summary

Fatigue affects 68% of primary biliary cirrhosis (PBC) patients, often linked to poor sleep and depression, not liver disease severity. Understanding these connections is key for managing PBC symptoms.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Clinical Medicine

Background:

  • Fatigue is a common and disabling symptom in patients diagnosed with primary biliary cirrhosis (PBC).
  • Primary biliary cirrhosis (PBC) is a chronic liver disease affecting predominantly women.

Purpose of the Study:

  • To investigate the relationship between fatigue and sleep quality, depression, and liver disease severity in PBC patients.
  • To assess the prevalence of fatigue in a cohort of primary biliary cirrhosis patients.

Main Methods:

  • Validated self-report questionnaires were used to measure fatigue, sleep quality, and depression.
  • Liver biochemistry and metabolic tests were performed to rule out other causes of fatigue.
  • Patient-reported fatigue and observer-rated depression were recorded, along with ursodeoxycholic acid (UDCA) use.

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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

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Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
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Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

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Related Experiment Videos

Last Updated: Jul 20, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

Main Results:

  • 68% of primary biliary cirrhosis patients reported long-term fatigue.
  • Fatigue Severity Score (FSS) correlated with sleep quality but not with disease severity markers (bilirubin, Mayo Risk Score, UDCA use).
  • Patients experiencing fatigue reported poorer sleep quality and higher depression scores compared to non-fatigued patients.

Conclusions:

  • Long-term fatigue is highly prevalent in primary biliary cirrhosis but is not associated with liver disease severity.
  • Poor sleep quality and depression are significant contributing factors to fatigue in primary biliary cirrhosis patients.