Related Experiment Video
Updated: Jul 15, 2026
08:52
Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
Published on: August 16, 2015
Abnormalities in cell cycle control in cancer and their clinical implications
A Sgambato1, G Flamini, A Cittadini
1Centro di Ricerche Oncologiche Giovanni XXIII, Catholic University, Rome, Italy.
Tumori
|November 24, 1998
Summary
Altered cell cycle gene functions drive cancer by disrupting cell growth and stability, promoting tumor development. This review examines cyclins, their abnormalities in human tumors, and clinical relevance.
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Cell cycle gene dysregulation is implicated in cancer development.
- Aberrant cell proliferation and genomic instability are hallmarks of cancer.
Purpose of the Study:
- To review the role of cyclins and related genes in mammalian cell cycle control.
- To summarize genetic abnormalities in human tumors.
- To discuss potential clinical implications.
Main Methods:
- Literature review of current research on cell cycle genes.
- Analysis of genetic alterations in human cancers.
- Synthesis of findings related to clinical applications.
Main Results:
- Cyclins and related proteins are critical regulators of the cell cycle.
- Specific cyclin gene abnormalities are frequently observed in various human tumors.
- These alterations correlate with tumor progression and patient outcomes.
Conclusions:
- Understanding cell cycle gene alterations is crucial for cancer research.
- Targeting cell cycle pathways offers potential therapeutic strategies.
- Further investigation is needed to fully elucidate clinical implications.
Related Concept Videos
01:04What is the Cell Cycle?
The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
02:34Inhibition of Cdk Activity
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
00:56What is the Cell Cycle?
The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
02:34Inhibition of CDK Activity
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...