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[Lomefloxacin in phthisiatric practice]

V K Grishin1, T E Polunina

  • 1Central Military Clinical Tuberculosis Hospital, Moscow.

Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
|November 24, 1998
PubMed
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Lomefloxacin effectively treated drug-induced hepatitis in tuberculosis patients, normalizing liver enzymes and improving tuberculosis treatment. This safe and efficient fluoroquinolone offers a valuable option for managing co-occurring conditions.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Drug-induced liver injury is a significant concern in tuberculosis treatment.
  • Antitubercular drugs can cause hepatitis, complicating patient management.
  • Alternative or adjunctive therapies are needed for patients with hepatitis receiving antitubercular treatment.

Purpose of the Study:

  • To evaluate the efficacy and safety of lomefloxacin in treating hepatitis caused by antitubercular agents.
  • To assess the impact of lomefloxacin on liver enzyme activity and tuberculosis progression.
  • To determine if lomefloxacin facilitates the continuation of essential antitubercular therapy.

Main Methods:

  • A trial group of 20 patients with drug-induced hepatitis (elevated liver enzymes) due to antitubercular agents were enrolled.

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  • Patients received a 4-week course of lomefloxacin (400 mg twice daily).
  • Efficacy was assessed clinically and through laboratory/instrumental investigations, excluding viral hepatitis markers.

    • Main Results:

    • Lomefloxacin treatment led to normalization of liver enzyme activity in patients with drug-induced hepatitis.
    • A favorable course of the primary tuberculosis disease was observed.
    • Tubercle bacilli isolation was discontinued in 70% of patients receiving combined therapy.
    • Lomefloxacin demonstrated a good safety profile.

    Conclusions:

    • Lomefloxacin is a safe and effective agent for treating hepatitis in tuberculosis patients receiving antitubercular drugs.
    • Lomefloxacin facilitates the continuation of antitubercular therapy in patients with drug-induced liver injury.
    • Combined therapy with lomefloxacin and antitubercular agents improves outcomes and reduces bacillary load.