Capillary haemangiomas in association with morning glory disc anomaly
1Academic Hospital, University of Uppsala, Sweden.
Insights
Extensive capillary hemangiomas in children are linked to ocular malformations, particularly morning glory disc anomaly (MGDA). This association, including other congenital defects, highlights the need for comprehensive evaluation in affected children.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Medical Genetics
Background:
- Capillary hemangiomas are common pediatric vascular tumors.
- While often isolated, systemic associations can occur.
- Ocular malformations require thorough investigation in pediatric cases.
Observation:
- Three children presented with extensive capillary hemangiomas.
- All cases exhibited morning glory disc anomaly (MGDA) in one eye.
- Associated anomalies included microphthalmos, corpus callosum agenesis, sclerocornea, and congenital heart defects.
Findings:
- A novel association between extensive capillary hemangiomas and MGDA is reported.
- This combination of vascular and ocular anomalies was not previously documented.
- The findings suggest a potential shared embryological origin for these defects.
Implications:
- Highlights the importance of ophthalmological screening in children with extensive capillary hemangiomas.
- Suggests a need for systemic evaluation in cases of capillary hemangioma with MGDA.
- Informs understanding of rare congenital anomaly associations and their embryogenesis.
Purpose And Method:
Capillary haemangiomas in children are usually isolated, but may have systemic associations. This accords with our finding of ocular malformations, especially "morning glory disc anomaly" (MGDA), in three children which are described.
Results:
All three children had extensive capillary haemangiomas in combination with MGDA in one eye. One of the children also had microphthalmos in one eye and a partial agenesis of the corpus callosum. Another child had sclerocornea in one eye and congenital heart defects.
Conclusion:
An association of extensive capillary haemangiomas with MGDA is described. The embryological timing of such defects as well as investigation of the children is discussed. Extensive haemangiomas have not previously, to our knowledge, been described in association with MGDA.
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