Related Experiment Video
Updated: Jul 19, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
Combined toxicity of methanol and formic acid: two cases of methanol poisoning
H Kinoshita1, I Ijiri, S Ameno
1Department of Forensic Medicine, Kagawa Medical University, Kita, Japan. kinochin@kms.ac.jp
Abstract:
Two fatalities caused by methanol ingestion are presented. Quantitative analysis of methanol and formic acid using head-space gas chromatography showed concentrations of methanol and formic acid in the femoral blood of each subject of 2.19 mg/ml and 0.41 mg/ml, and 1.96 mg/ml and 0.38 mg/ml, respectively. We concluded that death was due to methanol ingestion and the mechanism causing death involved the combined effects of the anesthetic action of methanol itself and metabolic acidosis by formic acid. Forensic toxicokinetic analysis indicated that both victims had ingested about 100 g of methanol or more.
Related Concept Videos
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Drug Toxicity: Overview
Drug toxicity: Drug–Drug Interaction
Toxidromes: Clinical Features
Pharmaceutical Poisoning: Potential Scenarios
Pharmaceutical Poisoning: Treatment Strategies

