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Desmoplastic fibroblastoma

J M Junkins-Hopkins1, W C Johnson

  • 1Department of Dermatology, University of Pennsylvania, Philadelphia, USA.

Journal of Cutaneous Pathology
|November 24, 1998
PubMed
Summary
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A rare fibrous soft-tissue tumor presenting as a cutaneous and subcutaneous nodule was identified. Histologic analysis revealed characteristic fibroblasts, abundant mucin, and mast cells, aiding in diagnosis.

Area of Science:

  • Dermatopathology
  • Soft Tissue Oncology
  • Surgical Pathology

Background:

  • Distinctive fibrous soft-tissue tumors have been previously reported in subcutaneous and intramuscular locations.
  • These tumors present a diagnostic challenge due to their unique histologic features.

Observation:

  • A case of a 48-year-old woman with a 2-cm cutaneous and subcutaneous nodule on the left arm is presented.
  • The nodule exhibited features consistent with previously described fibrous soft-tissue tumors.

Findings:

  • Excisional biopsy revealed a well-circumscribed tumor replacing dermal and subcutaneous tissue.
  • Histology showed hypocellularity with spindled fibroblasts dissecting collagen bundles, abundant mucin (Alcian blue positive), and mast cells.
  • Immunohistochemistry demonstrated positivity for Vimentin and Factor XIIIa, with negativity for S-100, desmin, actin, and keratin.

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Implications:

  • This case expands the known clinical presentations of this rare fibrous tumor.
  • Accurate histologic and immunohistochemical characterization is crucial for differentiating this entity from other soft-tissue neoplasms.
  • Further research may elucidate the specific cell of origin and behavior of this tumor.