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Updated: Aug 8, 2026

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
Correlation of cecal microflora of HLA-B27 transgenic rats with inflammatory bowel disease
A B Onderdonk1, J A Richardson, R E Hammer
1Channing Laboratory, Departments of Medicine and Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. ABONDERDON2BICS.BWH.HARVARD.EDU
Abstract:
Transgenic rats with a high level of expression of the human major histocompatibility complex class I molecule HLA-B27 develop chronic inflammatory bowel disease (IBD) and arthritis. Assessment of the cecal microflora showed a rise in numbers of Escherichia coli and Enterococcus spp., corresponding to the presence and severity of IBD in these rats.
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