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CD30: expression and function in health and disease
1The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-3639, Japan.
Insights
CD30, a tumor necrosis factor receptor superfamily member, is expressed on lymphocytes and lymphoid neoplasms. Its ligand (CD30L) is found on various immune cells, suggesting a role in co-stimulatory immune signals.
Area of Science:
- Immunology
- Molecular Biology
- Cell Biology
Background:
- CD30 is a marker for Hodgkin's lymphoma cells.
- CD30 and CD30L belong to the TNF receptor and TNF superfamilies.
- CD30 is expressed on specific lymphocytes and lymphoid neoplasms.
Purpose of the Study:
- To characterize CD30 and CD30L.
- To understand the expression patterns of CD30 and CD30L.
- To elucidate the biological functions and signal transduction of CD30.
Main Methods:
- Cloning and characterization of CD30 and CD30L cDNAs.
- Analysis of CD30 and CD30L expression in various cell types.
- Investigation of CD30 signal transduction pathways.
Main Results:
- CD30 and CD30L were identified as members of the TNFR and TNF superfamilies.
- Expression of CD30 is largely restricted to specific immune cells and lymphoid neoplasms.
- CD30 signal transduction involves TNFR-associated factors (TRAFs).
Conclusions:
- CD30 plays a role in immune regulation, particularly co-stimulation.
- The diverse biological functions of CD30 are mediated through TRAF proteins.
- Further research is needed to fully understand CD30 signaling mechanisms.
Abstract:
CD30 was originally described as a marker of Hodgkin's and Reed-Sternberg cells in Hodgkin's lymphoma. Cloning and characterization of cDNAs encoding CD30 and its ligand (CD30L) established these proteins as members of the tumor necrosis factor receptor (TNFR) and tumor necrosis factor (TNF) superfamilies, respectively. Expression of CD30 is mostly restricted to virus-infected lymphocytes, neoplasms of lymphoid origin and a subset of activated T cells which produce Th2-type cytokines. The ligand is present on activated T cells, resting B cells, granulocytes, and the medulla of the thymus (epithelial cells and Hassal's corpuscles) as well as in various leukemia cells. The biological function of CD30 is pleiotropic but has come to be understood in the context of co-stimulatory signals. Signal transduction of CD30 utilizes signal transducers, TNFR-associated factors (TRAF1, 2, 3 and 5), which are shared by other TNFR family members. Mechanisms of signal transduction leading to diverse biological functions remain to be elucidated.