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CD30: expression and function in health and disease

R Horie¹, T Watanabe

¹The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-3639, Japan.

Seminars in Immunology

|November 25, 1998

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CD30, a tumor necrosis factor receptor superfamily member, is expressed on lymphocytes and lymphoid neoplasms. Its ligand (CD30L) is found on various immune cells, suggesting a role in co-stimulatory immune signals.

Area of Science:

Immunology
Molecular Biology
Cell Biology

Background:

CD30 is a marker for Hodgkin's lymphoma cells.
CD30 and CD30L belong to the TNF receptor and TNF superfamilies.
CD30 is expressed on specific lymphocytes and lymphoid neoplasms.

Purpose of the Study:

To characterize CD30 and CD30L.
To understand the expression patterns of CD30 and CD30L.
To elucidate the biological functions and signal transduction of CD30.

Main Methods:

Cloning and characterization of CD30 and CD30L cDNAs.
Analysis of CD30 and CD30L expression in various cell types.
Investigation of CD30 signal transduction pathways.

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Main Results:

CD30 and CD30L were identified as members of the TNFR and TNF superfamilies.
Expression of CD30 is largely restricted to specific immune cells and lymphoid neoplasms.
CD30 signal transduction involves TNFR-associated factors (TRAFs).

Conclusions:

CD30 plays a role in immune regulation, particularly co-stimulation.
The diverse biological functions of CD30 are mediated through TRAF proteins.
Further research is needed to fully understand CD30 signaling mechanisms.