Failure of autologous stem cell transplantation in refractory thrombocytopenic purpura
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Updated: Oct 27, 2026

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
Published on: December 27, 2017
A M Marmont1, M T van Lint, D Occhini
1II Division of Haematology and Stem Cell Transplantation Centre, S Martino's Hospital, Genova, Italy.
Abstract:
A 44-year-old man with splenectomised refractory autoimmune thrombocytopenic purpura (AITP) of 10 years' duration underwent an autologous, T cell-depleted marrow transplant following conditioning with thiotepa and CY. There was no response to the transplant procedure. This is the fourth case in the literature to show failure following autologous stem cell transplantation, although complete, steroid-independent remissions were obtained in the first two patients for over 1 year.
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