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Glaucoma and vasospasm

D C Broadway1, S M Drance

  • 1Department of Ophthalmology, University of British Columbia, Vancouver, Canada.

The British Journal of Ophthalmology
|November 26, 1998
PubMed
Summary
This summary is machine-generated.

Glaucoma subtypes are linked to specific risk factors like vasospasm and cardiovascular disease, independent of intraocular pressure. Cold extremities may help identify focal ischemic glaucoma.

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Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Glaucoma Research

Background:

  • Glaucoma encompasses diverse optic disc appearances, potentially representing distinct subgroups.
  • Understanding these subgroups is crucial for targeted diagnosis and treatment.

Purpose of the Study:

  • To investigate the vasoactivity associated with four distinct glaucomatous optic disc appearances.
  • To identify potential risk factors specific to primary open-angle glaucoma (POAG) subgroups.

Main Methods:

  • Selected patients with four specific optic disc types: focal ischemic, myopic glaucomatous, senile sclerotic, and generalized cup enlargement.
  • Assessed peripheral vasospasm using laser Doppler flowmetry, alongside detailed patient histories.
  • Employed statistical analyses including ANOVA, t-tests, and chi-squared tests to evaluate group differences.

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Main Results:

  • Focal ischemic discs were more prevalent in women and associated with higher rates of vasospasm, migraine, and cold extremities.
  • Senile sclerotic discs showed a higher prevalence of cardiovascular and thyroid disease, with older mean age.
  • Smoking was not found to be related to optic disc type.

Conclusions:

  • Vasospasm and cardiovascular disease appear as specific risk factors for glaucoma subgroups, potentially independent of intraocular pressure.
  • Cold extremities may serve as a simpler indicator for focal ischemic glaucoma compared to laser Doppler flowmetry.