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Optic disc morphology in pigmentary glaucoma

J B Jonas1, A Dichtl, W M Budde

  • 1Department of Ophthalmology, University Erlangen-Nürnberg, Germany.

The British Journal of Ophthalmology
|November 26, 1998
PubMed
Summary

Pigmentary glaucoma eyes do not show unique optic disc morphology compared to primary open angle glaucoma, despite higher intraocular pressure. This suggests optic nerve head appearance is not a key differentiator in pigmentary glaucoma.

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[Not Available].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2014

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Optic Nerve Head Morphology

Background:

  • Pigmentary glaucoma is characterized by pigment dispersion syndrome.
  • Anterior segment morphology in pigmentary glaucoma is distinct.
  • Optic nerve head (ONH) morphology in pigmentary glaucoma requires further investigation.

Purpose of the Study:

  • To compare the ONH morphology between eyes with pigmentary glaucoma and primary open angle glaucoma (POAG).
  • To determine if pigmentary glaucoma exhibits a pathognomonic ONH morphology.

Main Methods:

  • Morphometric evaluation of optic disc photographs from 62 pigmentary glaucoma patients and 566 POAG patients.
  • Comparison of ONH parameters including optic disc size and shape, neuroretinal rim, optic cup depth, parapapillary atrophy zones, retinal vessel diameter, disc hemorrhages, and retinal nerve fiber layer defects.

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  • Statistical analysis to compare groups, controlling for visual field defect and neuroretinal rim area.

    • Main Results:

    • No significant differences were found in ONH size, shape, neuroretinal rim configuration, optic cup depth, alpha zone, retinal vessel diameter, disc hemorrhages, or localized retinal nerve fiber layer defects between pigmentary glaucoma and POAG groups.
    • The beta zone of parapapillary atrophy was slightly smaller in the pigmentary glaucoma group, though not statistically significant (p=0.06).
    • Mean maximal intraocular pressure and intraocular pressure amplitude were significantly higher in the pigmentary glaucoma group (p<0.001).

    Conclusions:

    • Eyes with pigmentary glaucoma do not display a pathognomonic ONH or retinal nerve fiber layer morphology compared to POAG.
    • Despite higher intraocular pressure peaks and amplitude in pigmentary glaucoma, ONH morphology remains similar to POAG.
    • The slightly smaller beta zone in pigmentary glaucoma may be associated with elevated intraocular pressure.