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Serum leptin in obese patients with Laron syndrome before and during IGF-I treatment
Z Laron1, A Silbergeld, P Lilos
1Endocrine & Diabetes Research Unit, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Journal of Pediatric Endocrinology & Metabolism : JPEM
|November 26, 1998
Abstract:
Fifteen patients with primary GH resistance (Laron syndrome, LS) were studied before and during 6 months of daily replacement treatment with IGF-I. The main findings were that patients with LS and normal or high serum GH binding protein (GHBP) were less obese than those with a negative GHBP, and that serum leptin levels varied with body mass as in other types of obesity.

