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Functional responses of neonatal chicken and turkey heterophils following stimulation by inflammatory agonists

M H Kogut1, C Holtzapple, V K Lowry

  • 1Food Animal Protection Research Laboratory, Agricultural Research Service, USDA, College Station, TX 77845, USA.

American Journal of Veterinary Research
|November 26, 1998
PubMed

Insights

Neonatal chicken and turkey heterophils show functional responses to inflammatory agonists like ionomycin and opsonized zymosan, similar to mature birds. These findings aid in understanding avian immune responses and controlling poultry diseases.

Area of Science:

  • Avian immunology
  • Cellular immunology
  • Innate immunity

Background:

  • Heterophils are key innate immune cells in poultry.
  • Understanding neonatal immune responses is crucial for disease prevention.

Purpose of the Study:

  • To investigate the functional responses of neonatal chicken and turkey heterophils to inflammatory agonists.
  • To compare neonatal heterophil activation with mature avian heterophils.

Main Methods:

  • Isolated heterophils from 1-day-old chickens and turkeys.
  • Stimulated heterophils with ionomycin, PMA, OZ, and FMLP.
  • Assessed functional responses including shape change, adherence, phagocytosis, calcium influx, and oxidative burst.

Main Results:

  • Neonatal chicken and turkey heterophils did not respond to FMLP.
  • Ionomycin and OZ induced significant responses in both species.
  • PMA stimulated chicken heterophils but not turkey heterophils.

Conclusions:

  • Neonatal avian heterophil activation mechanisms are similar to those in mature birds.
  • Stimulation with agonists alters the function of neonatal avian heterophils.
  • This research contributes to controlling bacterial diseases in poultry.
Abstract

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