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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Related Experiment Video

Updated: Jul 25, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
10:41

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

Published on: January 13, 2013

Serum erythromycin levels in pregnancy

B Larsen1, D D Glover

  • 1Department of Microbiology, Marshall University School of Medicine, Huntington, West Virginia, USA.

Clinical Therapeutics
|November 26, 1998
PubMed
Summary

Erythromycin absorption and serum levels appear reduced in pregnant women during their third trimester. Severe gastrointestinal side effects may indicate subtherapeutic drug concentrations, potentially impacting treatment effectiveness.

Area of Science:

  • Pharmacology
  • Maternal-Fetal Medicine
  • Infectious Diseases

Background:

  • Erythromycin is the standard treatment for chlamydial infections in pregnant women.
  • Limited pharmacokinetic data exists for erythromycin use during pregnancy, especially in the third trimester.

Purpose of the Study:

  • To investigate the pharmacokinetic profile of oral erythromycin base in pregnant women, particularly during the third trimester.
  • To assess erythromycin absorption and peak serum levels in relation to gestational stage.

Main Methods:

  • A study involving 10 pregnant women with chlamydial infection, with 7 in the third trimester and 3 in the second.
  • Serum samples were collected at timed intervals (0.5, 1, 2, 3, 4 hours) after a 500-mg oral dose of erythromycin base.
  • Analysis focused on determining erythromycin absorption rates and peak serum concentrations.

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Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)
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Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)

Published on: July 31, 2021

Related Experiment Videos

Last Updated: Jul 25, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
10:41

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

Published on: January 13, 2013

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
09:04

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)

Published on: July 31, 2021

Main Results:

  • Erythromycin absorption was delayed, and peak serum levels were lower in the third trimester compared to second-trimester data.
  • Two women in the third trimester had undetectable erythromycin serum levels throughout the study period.
  • These two women also reported the most severe gastrointestinal adverse events.

Conclusions:

  • Third-trimester pregnancy may be associated with diminished erythromycin absorption and lower serum concentrations.
  • Severe gastrointestinal symptoms could be a predictor of subtherapeutic erythromycin levels in late pregnancy.
  • Further research is needed to confirm these findings and their clinical implications for chlamydia treatment outcomes.