[Chronic infection of diploid cells of human embryo musculocutaneous tissue]

T A Bektemirov, S A Moĭsiadi, E N Prokudina-Kantorovich

|May 1, 1976

Abstract:

A model of chronic influenza infection of a strain of human embryo skin-muscle tissue diploid cells (KM WSN) was developed. When the cells were propagated without medium changes, they regularly produced virus in low infectious titres and hemagglutinins in titers of 1 : 2 to 1 : 4. Frequent medium changes caused more intensive infectious virus reproduction with no or very poor hemagglutinin accumulation. Superinfection of KM WSN cultures even with frequent medium changes led to a marked reduction in the amount of infectious virus production with no detectable interferon. The WSN KM virus was found to differ from the initial variant by a number of markers. The observed pattern of virus production suggests a mechanism of persistence in this system in connection with the interfering effect of the defective virus produced by the cells.

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Abstract:

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