[Effect of antimacrophage serum on immunologic responsiveness in mice vaccinated against influenza]

Inoculation of mice with antiserum to peritoneal exudate cell on the eve of intraperitoneal immunization with influenza A2 virus delays an immunologic response as manifested by an increase in the inductive phase of antibody formatin and a slower rise of antibody titre. The immunodepressive effect of the anti-macrophage serum corresponds to inhibition of the activity of macrophages and the lack of plasma cell reaction in the thymus. The anti-macrophage serum does not influence the development of secondary immune response which indicates that it affects the antigen-reacting cells.