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Spectrofluorimetric determination of tacrine in pharmaceuticals and spiked human serum
I Aparico1, M A Bello, M Callejón
1Department of Analytical Chemistry, Faculty of Chemistry, Seville, Spain.
The Analyst
|November 27, 1998
Abstract:
A spectrofluorimetric method to determine tacrine is proposed and applied to the determination of tacrine in human serum and pharmaceuticals. The fluorimetric method allows the determination of 1-70 ng ml-1 of tacrine in aqueous solutions containing acetic acid-sodium acetate buffer (pH 5.6) with lambda exc = 242 nm and lambda em = 362 nm.