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Alterations in kidney enzyme pattern in acute hypervitaminosis A
O M Alarcón1, J Reinosa Fuller, G García de Méndez
1Universidad de Los Andes, Mérida, Venezuela.
Archivos Latinoamericanos De Nutricion
|November 27, 1998
Summary
Acute hypervitaminosis A significantly alters kidney enzyme activity in rats. Excessive vitamin A intake increased certain enzymes like acid maltase and transaminases while decreasing others such as lipase and arginase.
Area of Science:
- Biochemistry
- Toxicology
- Nephrology
Background:
- Excessive vitamin A intake is linked to kidney pathologies.
- Limited data exists on kidney enzyme activity during acute hypervitaminosis A.
Purpose of the Study:
- To investigate kidney enzymatic alterations in rats with acute hypervitaminosis A.
- To correlate specific enzyme activity changes with varying doses of vitamin A palmitate.
Main Methods:
- Rats received daily intramuscular injections of vitamin A palmitate (10,000–100,000 IU) for seven days.
- Control group received sodium palmitate injections.
- Kidney enzyme activities were measured and compared between groups.
Main Results:
- All tested doses of vitamin A palmitate increased acid maltase, transaminases (GOT, GPT), alkaline phosphatase (ALP), and acid protease activity.
- Higher doses (50,000 and 100,000 IU) led to decreased amylase, lipase, and arginase activity.
- Enzyme changes were dose-dependent.
Conclusions:
- Acute hypervitaminosis A induces significant enzymatic changes in the kidney.
- These alterations may be associated with kidney necrosis and lysosomal hydrolase release.
- Further research is needed to elucidate the precise mechanisms.