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Infusional 5-FU: historical evolution, rationale, and clinical experience
1Cancer Center of Boston, Massachusetts, USA.
Oncology (Williston Park, N.Y.)
|November 27, 1998
Summary
5-fluorouracil (5-FU) is a chemotherapy drug used for various cancers. Advances in its administration and biochemical modulation enhance its effectiveness and patient convenience.
Area of Science:
- Oncology
- Pharmacology
Background:
- 5-fluorouracil (5-FU) has been a cornerstone chemotherapy agent for over 40 years.
- It is widely used in treating gastrointestinal, breast, head and neck, and bladder cancers.
Observation:
- Optimal administration schedules and the role of biochemical modulation for 5-FU are subjects of ongoing research.
- Infusional 5-FU is the standard for several cancers, including head and neck, esophageal, gastric, rectal, and anal cancers.
Findings:
- The mechanism of 5-FU's cytotoxic effect varies with administration schedule and modulation strategies.
- Debate continues regarding optimal infusion duration, dose intensity, and the necessity of biochemical modulation for infusional 5-FU.
Implications:
- New oral formulations of 5-FU and dihydropyrimidine dehydrogenase (DPD) inhibitors offer potential improvements.
- These advancements may eliminate the need for intravenous administration and infusion pumps, enhancing patient convenience and therapy.
- Manipulating 5-FU metabolism holds promise for incremental therapeutic gains.