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Related Experiment Videos

Azelastine does not adversely affect aerobic performance

J L Chicharro1, A Lucía, A F Vaquero

  • 1Escuela de Enfermería, Facultad de Medicina, Universidad Complutense, Madrid, Spain.

The Journal of Sports Medicine and Physical Fitness
|November 27, 1998
PubMed
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Azelastine treatment for allergic rhinitis in active individuals did not negatively impact maximal aerobic capacity or submaximal performance. This study evaluated key physiological indicators like VO2 max and ventilatory threshold.

Area of Science:

  • Exercise Physiology
  • Allergy and Immunology

Background:

  • Allergic rhinitis affects physically active individuals, potentially impacting aerobic performance.
  • Azelastine is a common intranasal treatment for upper respiratory allergic symptoms.

Purpose of the Study:

  • To evaluate the effect of azelastine on physiological indicators of aerobic performance in subjects with allergic rhinitis.
  • To assess the clinical efficacy of azelastine in this population.

Main Methods:

  • Fifteen physically active males with allergic rhinitis (experimental group) and fifteen healthy controls underwent maximal incremental exercise testing.
  • Subjects were treated with intranasal azelastine (0.56 mg/day) for 5 days, with physiological variables measured before and after treatment.

Main Results:

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  • No significant changes in aerobic variables were observed in the control group.
  • The experimental group showed a significant decrease in peak heart rate (HR) post-treatment.
  • Minute ventilation (VE) at the ventilatory threshold (VT) significantly increased in the experimental group after azelastine treatment.

Conclusions:

  • Intranasal azelastine for allergic rhinitis does not appear to adversely affect maximal aerobic capacity.
  • Submaximal aerobic performance, indicated by VE at VT, may be enhanced or unaffected by azelastine treatment in active individuals.