Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecules associated with human Th1 or Th2 cells

F Annunziato1, G Galli, L Cosmi

  • 1Institute of Internal Medicine and Immunoallergology, University of Florence, Italy.

European Cytokine Network
|November 27, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case Report: A child with NFKB1 haploinsufficiency explaining the linkage between immunodeficiency and short stature.

Frontiers in immunology·2023
Same author

Dim artificial light at night alters gene expression rhythms and growth in a key seagrass species (Posidonia oceanica).

Scientific reports·2023
Same author

Elimination of Interface Energy Barriers Using Dendrimer Polyelectrolytes with Fractal Geometry.

ACS applied materials & interfaces·2023
Same author

Humoral and cellular responses after third dose of SARS-CoV-2 vaccine in myeloproliferative neoplasms patients on ruxolitinib therapy.

Leukemia research·2023
Same author

Semen impairment and occurrence of SARS-CoV-2 virus in semen after recovery from COVID-19.

Human reproduction (Oxford, England)·2021
Same author

Relationship between proinflammatory cytokines (Il-1beta, Il-18) and leukocyte telomere length in mild cognitive impairment and Alzheimer's disease.

Experimental gerontology·2020
Same journal

Co-expression of CCR7 and H3K9me3 identifies aggressive B-cell lymphoma with bone marrow infiltration and poor prognosis.

European cytokine network·2026
Same journal

Re-evaluating cytokine storm syndromes: dysregulated host defense or contextual immune adaptation?

European cytokine network·2026
Same journal

Propolis as a potential modulator of aryl hydrocarbon receptor signaling in inflammation.

European cytokine network·2026
Same journal

Association between interleukin-6 promoter polymorphisms and osteoporosis in javanese postmenopausal women.

European cytokine network·2026
Same journal

Study of interferon-stimulated gene 15 expression in the medulloblastoma context.

European cytokine network·2026
Same journal

Astilbin ameliorates propranolol-induced psoriasis-like lesions through restoring Th17/Treg immune homeostasis in lymph nodes.

European cytokine network·2026
See all related articles

Researchers identified surface molecules associated with human T helper 1 (Th1) and T helper 2 (Th2) cells. Combined detection of these molecules aids in characterizing immune responses and understanding effector cell regulation.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Human T helper (Th) cells differentiate into distinct subsets, including Th1 and Th2, crucial for adaptive immunity.
  • Specific surface molecules have been observed to associate with Th1 or Th2 cells during their activation and differentiation.
  • Identifying these molecules is key to understanding immune response pathways.

Purpose of the Study:

  • To review and summarize known surface molecules associated with human Th1 and Th2 cells.
  • To highlight the potential of these molecules as markers for characterizing immune responses.
  • To explore the implications of understanding these associations for effector cell function and regulation.

Main Methods:

  • Literature review of studies identifying surface markers on human Th1 and Th2 cells.

Related Experiment Videos

  • Compilation of molecules preferentially associated with Th1 cells (e.g., CD26, IFN-gamma, LAG-3, CCR5, CXCR3).
  • Compilation of molecules preferentially associated with Th2 cells (e.g., CD62L, CD30, CCR3, CCR4, CCR8, CXCR4).

    • Main Results:

    • Several surface molecules show preferential association with either Th1 or Th2 cells.
    • Th1-associated molecules include CD26, membrane IFN-gamma, LAG-3, CCR5, and CXCR3.
    • Th2-associated molecules include CD62L, CD30, CCR3, CCR4, CCR8, and CXCR4.

    Conclusions:

    • No single molecule is a definitive marker for human Th1 or Th2 cells.
    • Combined detection of these surface molecules can help characterize immune response pathways in vitro and in vivo.
    • Understanding the mechanisms behind these associations offers insights into effector cell programming and regulation.