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Thrombophilia and inflammatory bowel disease: does factor V mutation have a role?
H H Over1, S Ulgen, T Tuğlular
1Marmara University Medical School, Department of Gastroenterology, Istanbul, Turkey.
European Journal of Gastroenterology & Hepatology
|November 27, 1998
Summary
Factor V Leiden mutation is more common in Crohn's disease (CD) patients than in healthy individuals. This genetic factor was not found to be more frequent in ulcerative colitis (UC) patients.
Area of Science:
- Genetics
- Gastroenterology
- Thrombosis
Background:
- Inflammatory bowel disease (IBD) is associated with an increased risk of thromboembolism.
- Microvascular thrombosis may play a role in IBD pathogenesis.
- The factor V (FV) Leiden mutation, a known cause of thromboembolism, has an unknown role in IBD.
Purpose of the Study:
- To investigate the prevalence of FV Leiden in IBD patients.
- To compare FV Leiden frequency between IBD subtypes (UC and CD) and healthy controls.
Main Methods:
- DNA analysis using polymerase chain reaction (PCR) and ELISA.
- Genotyping for FV Leiden mutation in 63 IBD patients (43 UC, 20 CD) and 36 healthy controls.
- Determination of heterozygosity and homozygosity for FV Leiden alleles.
Main Results:
- FV Leiden mutation was significantly more frequent in Crohn's disease patients (45% heterozygous, 5% homozygous) compared to controls (11% heterozygous).
- No significant difference in FV Leiden frequency was observed between ulcerative colitis patients and controls.
- No correlation found between FV Leiden and disease activity, gender, or duration.
Conclusions:
- Factor V Leiden mutation is more prevalent in Crohn's disease patients.
- The findings suggest a potential link between FV Leiden and the etiology of Crohn's disease, warranting further investigation.
- FV Leiden does not appear to be a significant risk factor for ulcerative colitis.