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Clinical use of cisapride and its risk-benefit in paediatric patients
1Academic Children's Hospital, Free University of Brussels, Belgium.
European Journal of Gastroenterology & Hepatology
|November 27, 1998
Insights
This review examines cisapride
Area of Science:
- Pediatric Gastroenterology
- Pharmacology
Background:
- Gastrointestinal motility disorders are common in children.
- Cisapride has been used to treat various pediatric gastrointestinal conditions.
Purpose of the Study:
- To comprehensively review cisapride's use in pediatric clinical conditions.
- To discuss cisapride's safety profile in children.
Main Methods:
- Literature review of cisapride in pediatric patients.
- Analysis of clinical data and safety profiles.
Main Results:
- Cisapride is used for gastro-oesophageal reflux, respiratory issues, cystic fibrosis, and motility disorders.
- The safety profile in pediatric patients requires careful consideration.
Conclusions:
- Cisapride has diverse applications in pediatric gastroenterology.
- Further research on cisapride's long-term safety in children is warranted.
Abstract:
This paper provides a comprehensive review of the current knowledge on cisapride in different clinical conditions in children: different manifestations of gastro-oesophageal reflux, such as (excessive) regurgitation, oesophagitis, chronic respiratory disease or uncontrolled asthma, cystic fibrosis, chronic dyspepsia, constipation and pseudo-obstruction, and as an aid to small bowel capsule-biopsy. It discusses, in depth, the safety profile of cisapride in paediatric patients.