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Updated: Aug 11, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation
Published on: January 17, 2011
Complications of airway management in very-low-birth-weight infants
1Department of Pediatrics, St. Joseph's Health Centre, University of Western Ontario, London, Ont., Canada. odasilva@julian.uwo.ca
Insights
Endotracheal intubation complications in very-low-birth-weight infants are infrequent, with subglottic stenosis being rare. Less severe airway issues are common but treatable, guiding selective bronchoscopy use.
Area of Science:
- Neonatal intensive care
- Pediatric airway management
- Critical care medicine
Background:
- Endotracheal intubation is a common procedure in neonatal intensive care units.
- Complications can arise from intubation, impacting infant outcomes.
- Understanding incidence and risk factors is crucial for improving patient care.
Purpose of the Study:
- To determine the incidence of endotracheal intubation complications in very-low-birth-weight infants.
- To identify factors associated with these complications.
Main Methods:
- Prospective follow-up of 227 intubated infants (<1,501 g) over 22 months.
- Detailed recording of airway management events and clinical data.
- Analysis of factors linked to postextubation stridor.
Main Results:
- 4.8% of infants developed postextubation respiratory stridor.
- Factors associated with stridor included traumatic intubation, prolonged ventilation, multiple intubations, and bacterial colonization.
- Mild subglottic stenosis was found in one infant; airway edema and granulation tissue in three.
Conclusions:
- Subglottic stenosis is an infrequent complication in this population with current management.
- Less severe airway complications are common but clinically manageable.
- Bronchoscopy is recommended selectively for infants with airway obstruction evidence postextubation.
Objective:
To define the incidence of complications of endotracheal intubation and the factors associated with these complications.
Study Design:
During a 22-month period, 227 intubated infants weighing <1,501 g were followed prospectively in a neonatal intensive care unit. Detailed records of events associated with airway management were kept after every intubation, in addition to clinical data.
Results:
Eleven infants (4.8%) developed respiratory stridor after extubation which was treated with either systemic corticosteroids, racemic epinephrine and/or reintubation for respiratory failure. Four infants were submitted for bronchoscopy, mild subglottic stenosis with tracheal edema was found in 1 patient, granulation tissue and airway edema were noted in 3 infants. Traumatic intubation, prolonged ventilation, multiple intubations and bacterial colonization of the endotracheal tube were the factors associated with postextubation stridor.
Conclusions:
Subglottic stenosis is an infrequent complication of endotracheal intubation with current airway management of very-low-birth-weight infants. Less severe complications are still common, but they are usually amenable to clinical treatment. Bronchoscopy should be performed selectively only in infants with clinical evidence of airway obstruction after extubation.
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