Related Experiment Videos
[Systemic side effects of external corticoids: results of dermatologic studies in children with neurodermititis]
Insights
Prolonged corticosteroid therapy for atopic dermatitis in children frequently leads to adverse effects. Topical corticosteroid use in children with atopic dermatitis resulted in significant side effects, particularly in girls.
Area of Science:
- Pediatric Dermatology
- Pharmacovigilance
Context:
- Atopic dermatitis is a common chronic inflammatory skin condition in children.
- Corticosteroids are frequently prescribed for managing atopic dermatitis.
- This study investigated the outcomes of corticosteroid therapy in pediatric inpatients.
Purpose:
- To evaluate the prevalence and side effects of prolonged corticosteroid therapy in children with atopic dermatitis.
- To assess the impact of topical versus systemic corticosteroid administration.
Summary:
- Out of 111 children with atopic dermatitis, 83 (74.8%) received prolonged corticosteroid therapy.
- Topical corticosteroids were used in 60 children (54.1%), with 98.3% experiencing adverse effects.
- Irreversible body changes occurred due to transcutaneous absorption, more frequently in girls.
Impact:
- Highlights the significant risk of adverse events associated with prolonged corticosteroid use in pediatric atopic dermatitis.
- Underscores the need for careful monitoring and alternative treatment strategies to minimize side effects and irreversible changes.
Abstract:
Of 111 children with atopic dermatitis who were admitted as in-patients in a German aero-biological childrens clinic, 83 patients (74.8%) had been prescribed a prolonged corticosteroid therapy from their family doctor. For 60 children (54.1%) the corticosteroid application was topital, partly with occlusive dressing or with fluorinated preparations. The remaining 23 children (20.7%) were treated topically and systemically with corticosteroids. Of the 60 children whose atopic dermatitis was treated exclusively with topical corticosteroids, 59 patients (98.3%) showed undesirable side effects. Moreover, irreversible body changes developed through the transcutaneous absorptive processes, which were more evident and appeared more often in girls than in boys.