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Low-dose oral iron absorption test: establishment of a reference interval
N M Jensen1, M Brandsborg, A M Boesen
1Department of Medicine, Randers Central Hospital, Denmark.
Scandinavian Journal of Clinical and Laboratory Investigation
|December 1, 1998
Summary
The low-dose oral iron absorption test (OIAT) shows higher iron absorption in premenopausal women than in men or postmenopausal women. This study establishes reference intervals for OIAT, aiding in iron deficiency diagnosis.
Area of Science:
- Clinical Biochemistry
- Hematology
- Nutritional Science
Background:
- Iron deficiency is a global health concern.
- The low-dose oral iron absorption test (OIAT) measures intestinal iron absorption.
- Increased iron absorption is characteristic of iron deficiency.
Purpose of the Study:
- Establish reference intervals for the OIAT.
- Evaluate methods for presenting OIAT results.
- Recommend an optimal method for OIAT result presentation.
Main Methods:
- 122 healthy volunteers underwent the OIAT.
- 10 mg of oral iron sulfate was administered on an empty stomach.
- Serum iron levels were measured at baseline and 1, 2, and 3 hours post-ingestion.
Main Results:
- Maximum serum iron increase (Cmax) was significantly higher in females than males (p<0.001).
- Cmax was higher in premenopausal females compared to postmenopausal females and males (p<0.01).
- Suggested reference intervals: 0-34 µmol/L for premenopausal females, 0-11 µmol/L for males and postmenopausal females.
Conclusions:
- Iron absorption measured by OIAT differs between sexes and menopausal status.
- Premenopausal females exhibit higher iron absorption.
- Established reference intervals can improve OIAT's utility in diagnosing iron deficiency.
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