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Effects of risperidone on conditioned avoidance responding in male mice
M A Aguilar1, M Rodriguez-Arias, M I Marí-Sanmillán
1Facultad de Psicología, Universitat de Valencia, Spain.
Behavioural Pharmacology
|December 2, 1998
Summary
Risperidone reduced avoidance behaviors in mice, impacting learning and performance. These findings suggest risperidone acts similarly to other neuroleptics in behavioral paradigms.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Risperidone is an atypical antipsychotic used to treat schizophrenia and bipolar disorder.
- Its effects on cognitive functions and behavior in animal models require further elucidation.
Purpose of the Study:
- To investigate the impact of risperidone on active avoidance behavior in BALB/C mice.
- To compare risperidone's effects with those of other neuroleptic medications in a behavioral paradigm.
Main Methods:
- BALB/C mice were administered varying doses of risperidone (0.1, 0.5, 1 mg/kg).
- Active avoidance behavior was assessed across three acquisition sessions and one performance session.
- Behavioral parameters included avoidances, crossings, non-responses, and defecation.
Main Results:
- Risperidone decreased avoidance responses and crossings during acquisition and performance phases.
- Dose-dependent effects were observed, with higher doses showing more pronounced impacts.
- Risperidone also influenced non-responses and defecation, suggesting broader behavioral effects.
Conclusions:
- Risperidone exhibits neuroleptic-like effects in the active avoidance paradigm.
- The findings contribute to understanding risperidone's behavioral pharmacology.
- Further research may explore the specific neural mechanisms underlying these effects.