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Related Experiment Videos

Social influences on morphine conditioned place preference

T L Coventry1, P S D'Aquila, P Brain

  • 1Department of Psychology, University of Wales, UK.

Behavioural Pharmacology
|December 2, 1998
PubMed
Summary

Social defeat in dominant rats alters their reward processing, impairing morphine-induced place conditioning. This effect is linked to changes in social status following the defeat experience.

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Animal Behavior

Background:

  • Social defeat in dominant male rats can lead to reduced hedonic tone, indicated by decreased sucrose consumption.
  • The conditioned place preference (CPP) paradigm is a standard method for assessing reward-related learning and hedonic capacity.

Purpose of the Study:

  • To investigate how social defeat impacts hedonic capacity in male rats using the CPP paradigm.
  • To determine the influence of social status changes post-defeat on morphine-induced place conditioning.

Main Methods:

  • Established dominance hierarchies in male PVG rats and subjected dominant and singly housed rats to social defeat by Tryon Maze Dull (TMD) rats.
  • Assessed morphine-induced place conditioning (1 mg/kg i.p.) at various time points (1, 3, 7 days) post-defeat.

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  • Monitored changes in social status (dominance/submission) following defeat.

    • Main Results:

    • Dominant and singly housed rats initially showed place preference for morphine, while their submissive partners did not.
    • Three days post-defeat, defeated dominant rats lost their place preference for morphine, which was gained by their submissive partners.
    • Seven days post-defeat, rats that became submissive showed no conditioning, while those maintaining dominance did; isolated rats recovered conditioning by 3-7 days post-defeat.

    Conclusions:

    • Social defeat significantly influences morphine-induced place conditioning in male rats.
    • The experience of defeat and its impact on social status are critical factors modulating reward processing and hedonic capacity.