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Macromolecular synthesis contributes to nociceptive response to subcutaneous formalin injection in mice
S J Kim1, K S Thomas, A A Calejesan
1Department of Anesthesiology, Washington University in St. Louis, MO 63110, USA.
Neuropharmacology
|December 2, 1998
Abstract:
Subcutaneous formalin injection into the hindpaw produces two phases of nociceptive response: phase 1 and phase 2. Activation of N-methyl-D-aspartate (NMDA) receptors in the spinal cord during phase 1 is important for phase 2. We report here that phase 2 but not phase 1 requires new RNA and protein synthesis in the spinal cord.