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Borrelial lymphocytoma--a historical case
C E Sonck1, M Viljanen, P Hirsimäki
1Department of Dermatology, University of Turku, Finland.
Summary
A patient experienced recurrent erythema migrans after tick bites, developing a temporary lymphatic infiltrate in breast skin. Borrelial DNA was found in the infiltrate, which shared genetic markers with a later lymphoma diagnosis.
Area of Science:
- Dermatology
- Infectious Diseases
- Oncology
Background:
- Lyme disease, caused by Borrelia burgdorferi, is a tick-borne illness characterized by erythema migrans.
- Disseminated Lyme disease can manifest in various ways, sometimes mimicking other conditions.
Observation:
- A patient presented with two distinct episodes of erythema migrans following tick bites over a 20-year period.
- A significant lymphatic infiltrate developed in the mammary skin during the second episode, resolving spontaneously.
Findings:
- Borrelial DNA was identified in the breast lymphatic infiltrate via polymerase chain reaction.
- The infiltrate and a subsequent generalized lymphoma exhibited similar monoclonal immunoglobulin heavy chain gene rearrangements.
Implications:
- This case suggests a potential link between Borrelia infection and lymphoproliferative disorders.
- Further research is needed to explore the oncogenic potential of Borrelia burgdorferi infections.
