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A novel antiprotozoal aminosteroid from Saracha punctata
C Moretti1, M Sauvain, C Lavaud
1Institut Français de Recherche Scientifique pour le Développement en Coopération (ORSTOM), Unité de Recherche No. 45, 209-213 rue La Fayette 75480 Paris Cedex 10, France.
Journal of Natural Products
|December 3, 1998
Abstract:
A new aminosteroid, 3beta-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-beta-D-glucopyranosyl-eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 microM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 microM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.