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Updated: Aug 11, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
Published on: March 27, 2020
Emerging roles for PAX transcription factors in cancer biology
1University of Zurich, Dept. of Pediatrics, Switzerland. schafer@kispi.unizh.ch
Abstract:
Pax genes are transcription factors which act as essential control genes during the establishment of embryonic cell lineages. Recent evidence now demonstrates that their expression is deregulated by different mechanisms in several tumor types including Wilms' tumors, rhabdomyosarcomas, brain tumors and lymphomas. The oncogenic role of PAX proteins in tumor development is now subject of intensive investigations and may include stimulation of the rate of proliferation as well as inhibition of the apoptotic program. In addition, the expression of PAX genes in these cancers might serve as a diagnostic and probably also prognostic tool.
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When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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